HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Bromo-2-(2,2-dimethoxypropyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(2-Bromophenyl)propan-2-one | HCID 2734092 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Bromo-2-(2,2-dimethoxypropyl)benzene | HCID 59536429 | — |
Reaction Steps
2-Bromophenylacetone (4.45000 g, 21 mmol) was dissolved in 10 mL MeOH and trimethyl orthoformate (11 mL, 104 mmol) and hydrogen chloride, 4.0M solution in 1,4-dioxane (5.2 mL, 21 mmol) were added. The mixture was stirred for 1 h and neutralized carefully with DIEA (pH 7). The mixture was evaporated and filtered through a plug of silica providing 1-bromo-2-(2,2-dimethoxypropyl)benzene as a colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476297B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-23781c5df85b49ce81363cf3768034e1 |
| Source note | uspto-grants-2013_07 |