反应详情

2-Bromophenylacetone (4.45000 g, 21 mmol) was dissolved in 10 mL MeOH and trimethyl orthoformate (11 mL, 104 mmol) and hydrogen chloride, 4.0M solution in 1,4-dioxane (5.2 mL, 21 mmol) were added. The mixture was stirred for 1 h and neutralized carefully with DIEA (pH 7). The mixture was evaporated and filtered through a plug of silica providing 1-bromo-2-(2,2-dimethoxypropyl)benzene as a colorless liquid.

1. customThe mixture was evaporated
2. filtrationfiltered through a plug of silica