反应详情

温度

120 °C

6-Bromo-3-nitro-quinolin-4-ol (Fluorochem Ltd., Derbyshire, UK, 10 g, 37.2 mmol) was added to POCl3 (70 ml). The RM was stirred at 120° C. for 17 h. Then the RM was cooled with an ice-bath, before being slowly dropped onto ice-water. The precipitate was filtered and washed with cold water. The residue was dissolved in DCM, washed with brine, dried over Na2SO4, filtered and evaporated to give the title compound as a beige solid (HPLC tR 3.64 min (Method A))

1. temperatureThen the RM was cooled with an ice-bath
2. additionbefore being slowly dropped onto ice-water
3. filtrationThe precipitate was filtered
4. washwashed with cold water
5. dissolutionThe residue was dissolved in DCM
6. washwashed with brine
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. customevaporated