Isopropanol → 3-Bromo-5-(propan-2-yloxy)pyridine

HRID 445605Notes

Reaction equation

HRID 445605 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([OH:8])[CH:7]=1.[CH:9](O)([CH3:11])[CH3:10]>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH:9]([CH3:11])[CH3:10])[CH:7]=1

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 5995293-Bromo-5-hydroxypyridine

Product 1

HCID 105848083-Bromo-5-(propan-2-yloxy)pyridine

Procedure

The title compound was synthesized in a similar manner as described for Stage 29.1.1 using 3-bromo-5-hydroxypyridine (Aldrich, Buchs, Switzerland) and isopropanol (Merck, Dietikon, Switzerland) to give the title compound as a colorless oil. (HPLC: tR 2.92 min (Method A); M+H=216, 218 MS-ES).

Workup

  1. customThe title compound was synthesized in a similar manner

Sources & evidence

ORD record
ord-afeab43bba1444e7aaaf40b879ad7a5f
Source dataset
uspto-grants-2013_07
Patent number
US08476294B2

Reaction notes

Loading…