反应详情

A mixture of 4-(benzyloxy)-2-hydroxybenzaldehyde (1 g, 4.38 mol), 2-iodopropane (1.2 eq.) and potassium carbonate (2.5 eq.) in acetone (40 mL) was refluxed overnight. The reaction was cooled to room temperature and filtered through a celite plug, and concentrated to dryness. The crude material was purified by flash column chromatography with ethyl acetate and hexanes to provide 4-(benzyloxy)-2-isopropoxybenzaldehyde (698).

1. temperaturewas refluxed overnight
2. filtrationfiltered through a celite plug
3. concentrationconcentrated to dryness
4. customThe crude material was purified by flash column chromatography with ethyl acetate and hexanes