反应详情

5.3 g (25.5 mmoles) of 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methyl-methanamine and 6.8 g (25.5 mmoles) of 2-(3-bromopropyl)-1H-isoindole-1,3(2H)-dione are dissolved in 230 mL of acetone. 13 g (95 mmoles, 3.7 eq.) of potassium carbonate are added to the resulting solution. The mixture is then heated at reflux for 24 hours. After returning to ambient temperature, the potassium carbonate is filtered off and the filtrate is evaporated to dryness. The residue is taken up in water and extracted with dichloromethane. The organic phase is dried over MgSO4, filtered and evaporated to dryness. 9.7 g of expected product are obtained in the form of a pale yellow oil.

1. temperatureThe mixture is then heated
2. temperatureat reflux for 24 hours
3. customAfter returning to ambient temperature
4. filtrationthe potassium carbonate is filtered off
5. customthe filtrate is evaporated to dryness
6. extractionextracted with dichloromethane
7. dry with materialThe organic phase is dried over MgSO4
8. filtrationfiltered
9. customevaporated to dryness