反应详情

To a suspension of 4-acetylaminobenzenesulfonyl chloride (10 g, 43 mmol) in DME (103 mL) is added, at 0° C., tert-butylamine (9 mL, 86 mmol) in DME (103 mL). Next, the reaction mixture is stirred for 4 h at reflux. The solvent is removed and CHCl3 is added. The resulting suspension is filtered and the solid is washed with CHCl3, H2O and Et2O. The solid obtained is dried in vacuo to give 8.0 g of the product as a white solid (yield: 68%).

1. additionis added, at 0° C.
2. temperatureat reflux
3. customThe solvent is removed
4. additionCHCl3 is added
5. filtrationThe resulting suspension is filtered
6. washthe solid is washed with CHCl3, H2O and Et2O
7. customThe solid obtained
8. customis dried in vacuo