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HRID446156

反应详情

EQUATION

反应方程式

HRID 446156 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(C=O)cc1F
HCID67696

3-Fluoro-p-anisaldehyde

C8H7FO2

结构：CC(C)(C)NS(=O)(=O)c1ccc(N)cc1
HCID832627

4-amino-N-tert-butylbenzenesulfonamide

C10H16N2O2S

PRODUCTS

生成物

1
结构：COc1ccc(C=Nc2ccc(S(=O)(=O)NC(C)(C)C)cc2)cc1F
HCID11132250

未命名化合物

收率 99.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture of 4-amino-N-tert-butylbenzenesulfonamide (52.3 g, 0.23 mol, obtained in example 1), 3-fluoro-4-methoxybenzaldehyde (35.3 g, 0.23 mol) and toluene (2.5 L) is heated at reflux in a Dean-Stark for 24 h. The solvent is removed, yielding 83.5 g of the title compound (yield: quantitative).

WORKUP

后处理

  1. temperatureis heated
  2. temperatureat reflux in a Dean-Stark for 24 h
  3. customThe solvent is removed