HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 446172Generated: October 26, 2026
Phenyl isocyanate → N-(4-cyanopheny)-N-(1H-imidazol-1-yl)-N'-phenylurea
https://huagongshe.com/reaction/446172
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 4-[(1H-imidazol-1-yl)amino]benzonitrile | HCID 23018188 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-cyanopheny)-N-(1H-imidazol-1-yl)-N'-phenylurea | HCID 69455384 | — |
Reaction Steps
Phenyl isocyanate (3.6 ml, 32.6 mmol) was added to a solution of 4-[N-(1H-imidazol-1-yl)amino]benzonitrile (5 g, 27.17 mmol) in THF (50 ml). The mixture was stirred at 50° C. overnight and after evaporation was crystallised in acetone/EtOH to give white crystals (2.5 g, 30.3%, 178° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476455B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-9d739387e3b6469f8c4a265973962a77 |
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| Source note | uspto-grants-2013_07 |
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