反应详情

To a solution of 2-cyano-6-hydroxybenzothiazole (100 mg, 0.568 mmol) in 10 mL of acetone was added potassium carbonate (157 mg, 1.14 mmol), followed by 2-(trifluoromethyl)benzyl bromide (204 mg, 0.852 mmol). The mixture was then stirred at RT for about 5 hrs. The solvent was then removed under reduced pressure and the residue was dissolved in dichloromethane. The resultant solution was then extracted with dichloromethane. The organic phase was dried over sodium sulfate and purified by flash chromatography using dichloromethane. 148 mg of product was obtained.

1. customThe solvent was then removed under reduced pressure
2. dissolutionthe residue was dissolved in dichloromethane
3. extractionThe resultant solution was then extracted with dichloromethane
4. dry with materialThe organic phase was dried over sodium sulfate
5. custompurified by flash chromatography