反应详情

温度

65 °C

To a suspension of 0.30 g (0.86 mmol) of ethyl 8-anilino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate in a mixture of 10 mL of methanol and 10 mL of dimethylformamide, 5 mL of ethanolamine were added. The mixture was heated in a close bottle under stirring at 65° C. After 5 hours the solvent was removed, the residue redissolved with dichloromethane and washed with water. The organic layer was dried over Na2SO4 and evaporated. The residue was triturated with diethyl ether and the product collected by filtration (60% yield).

1. additionwere added
2. temperatureThe mixture was heated in a close bottle
3. customAfter 5 hours the solvent was removed
4. dissolutionthe residue redissolved with dichloromethane
5. washwashed with water
6. dry with materialThe organic layer was dried over Na2SO4
7. customevaporated
8. customThe residue was triturated with diethyl ether
9. filtrationthe product collected by filtration (60% yield)