反应详情

A solution of 2-(2-fluorophenyl)ethanol (5.5 g) and imidazole (8.0 g) in DMF (50 mL) was cooled in ice-water, treated with tert-butyldimethylchlorosilane (6.52 g), then removed as from the cooling bath and stirred at room temperature for 3.5 hours. The solution was poured into water and extracted three times with diethyl ether. The combined organic extracts were washed three times with water, once with brine, then dried over anhydrous magnesium sulphate and concentrated under reduced pressure to afford the subtitled compound as a colourless oil. Yield 9.9 g.

1. customremoved as from the cooling bath
2. additionThe solution was poured into water
3. extractionextracted three times with diethyl ether
4. washThe combined organic extracts were washed three times with water
5. dry with materialonce with brine, then dried over anhydrous magnesium sulphate
6. concentrationconcentrated under reduced pressure