反应详情

The mixture of 25 g (0.0792 mol) of (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl methanesulfonate and morpholine (69.37 mL, 0.792 mol) in 250 mL of dry THF under inert atmosphere was refluxed for 8 hours. The reaction was then cooled to room temperature, treated with diethylether and the solid filtered. The solution was evaporated affording the crude as a yellow oil that was purified through silica gel chromatography (eluant hexane/ethylacetate 6/4). 11.59 g of the title product were isolated (48% yield).

1. temperaturewas refluxed for 8 hours
2. filtrationthe solid filtered
3. customThe solution was evaporated
4. customaffording the crude as a yellow oil that
5. customwas purified through silica gel chromatography (eluant hexane/ethylacetate 6/4)