3-(3-(Hydroxymethyl)phenyl)propan-1-ol → 3-(4-(tert-Butyldimethylsilyloxy)butyl)benzaldehyde

HRID 446391Notes

Reaction equation

HRID 446391 reaction equation
OCC1C=C(CCCO)C=CC=1.[Si:13]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH2:31][OH:32])[CH:28]=[CH:29][CH:30]=1)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>>[Si:13]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:28]=[CH:29][CH:30]=1)[CH:31]=[O:32])([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 552676803-(3-(Hydroxymethyl)phenyl)propan-1-olHCID 58168515(3-(4-(tert-Butyldimethylsilyloxy)butyl)phenyl)methanol2×

Product 1

HCID 581686153-(4-(tert-Butyldimethylsilyloxy)butyl)benzaldehyde

Procedure

Prepared by the method of Aromatic Intermediate 18, step c using (3-(4-(tert-butyldimethylsilyloxy)butyl)phenyl)methanol [Aromatic Intermediate 19, step b] (0.72 g) in place of 3-(3-(hydroxymethyl)phenyl)propan-1-ol. Yield 0.64 g.

Sources & evidence

ORD record
ord-756352e5df8b4b83a9ef1e2fb98c67c7
Source dataset
uspto-grants-2013_07
Patent number
US08476265B2

Reaction notes

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