Isovaleryl chloride → 2-(2-Methylpropyl)-1,3-thiazole-4-carboxylic acid

HRID 446415Notes

Reaction equation

CC[CH:3]([C:6]1[S:7][CH:8]=[C:9]([C:11]([O:13]CC)=[O:12])[N:10]=1)[CH2:4][CH3:5].[CH3:16]C(C)CC(Cl)=O>>[CH2:3]([C:6]1[S:7][CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=1)[CH:4]([CH3:5])[CH3:16]

Participants

Reactant 2

HCID 66054Isovaleryl chloride

HCID 57989261Ethyl 2-(pentan-3-yl)thiazole-4-carboxylate

Product 1

HCID 235881542-(2-Methylpropyl)-1,3-thiazole-4-carboxylic acid

Procedure

Prepared by the method of Carboxylic Acid 3, using 3-methylbutanoyl chloride (10 mL) in place of 2-ethylbutanoyl chloride in step a. Yield 3.8 g.

Sources & evidence

ORD record: ord-58dfd9f58bd54577b2fec49daac123de
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08476265B2

Reaction notes

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