HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → Methyl 2-(4-methylpiperazino)-5-nitrobenzenecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Methyl 2-Fluoro-5-nitrobenzoate | HCID 11217860 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(4-methylpiperazino)-5-nitrobenzenecarboxylate | HCID 36405266 | — |
Reaction Steps
A solution of methyl 2-fluoro-5-nitro-benzoate (3.487 g, 17.511 mmol) and N-methylpiperazine (3.855 mL, 3.508 g, 35.022 mmol) in 30 mL of anhydrous methanol was heated to reflux for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541429B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-36509e16039c4f43b53665e1858e6db9 |
| Source note | uspto-grants-2013_09 |