反应详情

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

1. temperatureThe resulting solution was refluxed for 6 hours
2. customThe solvent was then removed in vacuo
3. customthe residue partitioned between dichloromethane and water
4. dry with materialThe organic layer was dried over sodium sulfate
5. customevaporated to dryness