反应详情

Tosic acid monohydrate (1.38 g) was added to a solution of N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-((4-(2-methylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanamide (0.68 g) in DCM (10 mL) and the resulting mixture stirred at RT until consumption of the acetal was complete (4 h). Saturated sodium bicarbonate solution (10 mL) was cautiously added and the mixture was stirred until bubbling ceased (10 min). The reaction mixture was diluted with DCM (50 mL) and the aqueous phase separated. The organic phase was washed with saturated sodium bicarbonate solution (2×20 mL) and brine (20 mL), dried over sodium sulphate, filtered and evaporated to give the subtitled compound as a gum. Yield 0.61 g.

1. custom(4 h)
2. customuntil bubbling
3. custom(10 min)
4. additionThe reaction mixture was diluted with DCM (50 mL)
5. customthe aqueous phase separated
6. washThe organic phase was washed with saturated sodium bicarbonate solution (2×20 mL) and brine (20 mL)
7. dry with materialdried over sodium sulphate
8. filtrationfiltered
9. customevaporated