Sodium Hydroxide → HCID 58168599, compound

HRID 446470Notes

Reaction equation

HRID 446470 reaction equation
[OH-].[Na+].C([O:6][CH2:7][CH2:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][CH2:15][N:16]2[CH2:36][CH2:35][C:19]3([O:24][CH2:23][CH2:22][N:21]([C:25]([C:27]4[N:28]=[C:29]([CH:32]([CH3:34])[CH3:33])[S:30][CH:31]=4)=[O:26])[CH2:20]3)[CH2:18][CH2:17]2)[CH:13]=1)(=O)C>CO>[OH:6][CH2:7][CH2:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][CH2:15][N:16]2[CH2:36][CH2:35][C:19]3([O:24][CH2:23][CH2:22][N:21]([C:25]([C:27]4[N:28]=[C:29]([CH:32]([CH3:33])[CH3:34])[S:30][CH:31]=4)=[O:26])[CH2:20]3)[CH2:18][CH2:17]2)[CH:13]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58168510HCID 58168510, compound

Product 1

HCID 58168599HCID 58168599, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

Aqueous sodium hydroxide (1M, 4.9 mL) was added to a solution of 2-(4-(2-(4(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)thiophen-2-yl)ethyl acetate [Example 78, step a] (1.0 g) in methanol (20 mL) and the resulting mixture was stirred for 1 hour at 20° C. The mixture was partitioned between ethyl acetate and brine and separated. The organic phase was dried, filtered and the solvent evaporated under reduced pressure to afford the subtitled compound. Yield 0.92 g.

Workup

  1. customThe mixture was partitioned between ethyl acetate and brine
  2. customseparated
  3. customThe organic phase was dried
  4. filtrationfiltered
  5. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-b34e81eb2d6c45b6a083f02321602ac7
Source dataset
uspto-grants-2013_07
Patent number
US08476265B2

Reaction notes

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