Sodium Hydroxide → HCID 58168599, compound

Participants

Reaction Conditions

Reaction Steps

Aqueous sodium hydroxide (1M, 4.9 mL) was added to a solution of 2-(4-(2-(4(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)thiophen-2-yl)ethyl acetate [Example 78, step a] (1.0 g) in methanol (20 mL) and the resulting mixture was stirred for 1 hour at 20° C. The mixture was partitioned between ethyl acetate and brine and separated. The organic phase was dried, filtered and the solvent evaporated under reduced pressure to afford the subtitled compound. Yield 0.92 g.

Provenance & Evidence