1,4-Dioxane hydrochloride → HCID 86761898, compound

HRID 446515Notes

Reaction equation

HRID 446515 reaction equation
[C:1]1([C:93]2[CH:98]=[CH:97][CH:96]=[CH:95][CH:94]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:92])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:91])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]2[CH:32]=[CH:31][C:30]([C:33](=[O:89])[N:34]([CH2:36][CH2:37][CH2:38][N:39]([C:41](=[O:88])[CH2:42][O:43][C@@H:44]3[C:52]4([CH2:57][CH2:56][N:55]([CH2:58][CH2:59][C@:60]5([C:81]6[CH:86]=[CH:85][C:84]([F:87])=[CH:83][CH:82]=6)[O:64][CH2:63][N:62]([C:65](=[O:80])[C:66]6[CH:71]=[C:70]([C:72]([F:75])([F:74])[F:73])[CH:69]=[C:68]([C:76]([F:79])([F:78])[F:77])[CH:67]=6)[CH2:61]5)[CH2:54][CH2:53]4)[C:51]4[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=4)[CH2:45]3)[CH3:40])[CH3:35])=[CH:29][C:28]=2[F:90])[CH3:19])[CH2:12][CH2:11]1.[ClH:99].O1CCOCC1>CO>[ClH:99].[ClH:99].[ClH:99].[C:1]1([C:93]2[CH:94]=[CH:95][CH:96]=[CH:97][CH:98]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:92])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:91])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]2[CH:32]=[CH:31][C:30]([C:33](=[O:89])[N:34]([CH2:36][CH2:37][CH2:38][N:39]([C:41](=[O:88])[CH2:42][O:43][C@@H:44]3[C:52]4([CH2:57][CH2:56][N:55]([CH2:58][CH2:59][C@:60]5([C:81]6[CH:86]=[CH:85][C:84]([F:87])=[CH:83][CH:82]=6)[O:64][CH2:63][N:62]([C:65](=[O:80])[C:66]6[CH:71]=[C:70]([C:72]([F:73])([F:74])[F:75])[CH:69]=[C:68]([C:76]([F:78])([F:77])[F:79])[CH:67]=6)[CH2:61]5)[CH2:54][CH2:53]4)[C:51]4[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=4)[CH2:45]3)[CH3:40])[CH3:35])=[CH:29][C:28]=2[F:90])[CH3:19])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86761899HCID 86761899, compound

Product 1

HCID 86761898HCID 86761898, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (148 mg) obtained in Example 13d was dissolved in methanol (1 mL), 4 N hydrochloric acid-dioxane (0.108 mL, 0.434 mmol) was added, and the solvent was evaporated under reduced pressure to give the title compound (127 mg; yield, 80%) as a white solid.

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c1cd872b1f8b4a309f72c5e427f15f20
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

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