1-(2-(Methylamino)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate → Methyl 7-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-7-oxoheptanoate

HRID 446533Notes

Reaction equation

HRID 446533 reaction equation
[C:1]([O:11][CH3:12])(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O-:9])=O.[C:13]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][C:20](=[O:32])[O:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH:30][CH3:31])[CH2:24][CH2:23]1>>[C:13]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][C:20]([O:21][CH:22]1[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][N:30]([CH3:31])[C:7](=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([O:11][CH3:12])=[O:10])[CH2:26][CH2:27]1)=[O:32]

Participants

3

Reactant 2

HCID 566436031-(2-(Methylamino)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamateHCID 857685117-Methoxy-7-oxoheptanoate

Product 1

HCID 66794003Methyl 7-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-7-oxoheptanoateYield 102.5%

Procedure

Monomethyl pimelate (79 mg, 0.450 mmol) and 1-[2-(methylamino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate (159 mg, 0.450 mmol) were used to give the title compound (235 mg; yield, 100%) as a colorless oily substance according to the method described in Example 12a.

Sources & evidence

ORD record
ord-00f5e686bed34d2daa323a760d0db9af
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

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