HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-(Methylamino)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate → Methyl 7-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-7-oxoheptanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-(Methylamino)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate | HCID 56643603 | — |
| Reactant | 7-Methoxy-7-oxoheptanoate | HCID 85768511 | — |
| Product | Methyl 7-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-7-oxoheptanoate | HCID 66794003 | 102.5% |
Reaction Steps
Monomethyl pimelate (79 mg, 0.450 mmol) and 1-[2-(methylamino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate (159 mg, 0.450 mmol) were used to give the title compound (235 mg; yield, 100%) as a colorless oily substance according to the method described in Example 12a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476253B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-00f5e686bed34d2daa323a760d0db9af |
| Source note | uspto-grants-2013_07 |