1,4-Dioxane hydrochloride → HCID 86761906, compound

HRID 446538Notes

Reaction equation

HRID 446538 reaction equation
[C:1]1([C:94]2[CH:99]=[CH:98][CH:97]=[CH:96][CH:95]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:93])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:92])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35](=[O:91])[N:36]([CH2:38][CH2:39][CH2:40][N:41]([C:43](=[O:90])[CH2:44][O:45][C@@H:46]3[C:54]4([CH2:59][CH2:58][N:57]([CH2:60][CH2:61][C@:62]5([C:83]6[CH:88]=[CH:87][C:86]([F:89])=[CH:85][CH:84]=6)[O:66][CH2:65][N:64]([C:67](=[O:82])[C:68]6[CH:73]=[C:72]([C:74]([F:77])([F:76])[F:75])[CH:71]=[C:70]([C:78]([F:81])([F:80])[F:79])[CH:69]=6)[CH2:63]5)[CH2:56][CH2:55]4)[C:53]4[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=4)[CH2:47]3)[CH3:42])[CH3:37])[CH:30]=2)[CH3:27])[CH3:19])[CH2:12][CH2:11]1.[ClH:100].O1CCOCC1>ClCCl>[ClH:100].[ClH:100].[ClH:100].[C:1]1([C:94]2[CH:95]=[CH:96][CH:97]=[CH:98][CH:99]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:93])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:92])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35](=[O:91])[N:36]([CH2:38][CH2:39][CH2:40][N:41]([C:43](=[O:90])[CH2:44][O:45][C@@H:46]3[C:54]4([CH2:59][CH2:58][N:57]([CH2:60][CH2:61][C@:62]5([C:83]6[CH:88]=[CH:87][C:86]([F:89])=[CH:85][CH:84]=6)[O:66][CH2:65][N:64]([C:67](=[O:82])[C:68]6[CH:69]=[C:70]([C:78]([F:79])([F:80])[F:81])[CH:71]=[C:72]([C:74]([F:75])([F:76])[F:77])[CH:73]=6)[CH2:63]5)[CH2:56][CH2:55]4)[C:53]4[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=4)[CH2:47]3)[CH3:42])[CH3:37])[CH:30]=2)[CH3:27])[CH3:19])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86761907HCID 86761907, compound

Product 1

HCID 86761906HCID 86761906, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (60.0 mg, 43.6 μmol) obtained in Example 41b was dissolved in dichloromethane (6 mL), a 4 N hydrochloric acid-1,4-dioxane solution (33 μL, 0.131 mmol) was added, and the mixture was stirred for 10 minutes and then concentrated under reduced pressure to give the title compound (32.4 mg; yield, 50%) as a white solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-242a7ef6e74e440da0c19e5dec87e909
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

Loading…