Hydrochloric Acid → (1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

HRID 44654Notes

Reaction equation

HRID 44654 reaction equation
C(OC([NH:8][C@@H:9]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:24].C(OCC)C>O1CCOCC1>[ClH:24].[N:12]1([C:10](=[O:11])[C@@H:9]([NH2:8])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57444168N-(tert-butoxycarbonyl)-(1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine

Product 1

HCID 45158390(1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochlorideYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.327 g of N-(tert-butoxycarbonyl)-(1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine was dissolved in 15 mL of dioxane and treated with 3.5 mL of HCl 4 M in dioxane overnight. The solvent was removed and the solid was triturated with diethylether yielding 920 mg of the product (yield 90%).

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-63869bfc633543abaf68ab221cb5e32d
Source dataset
uspto-grants-2013_09
Patent number
US08541429B2

Reaction notes

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