HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate → 1-{2-[{6-[({5-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}methyl)(2,2-dimethylpropyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate | HCID 86761901 | — |
| Reactant | tert-Butyl (3-{[(5-{[(2,2-dimethylpropyl)amino]methyl}-2-thienyl)carbonyl](methyl)amino}propyl)methylcarbamate | HCID 86761908 | — |
| Product | 1-{2-[{6-[({5-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-thienyl}methyl)(2,2-dimethylpropyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate | HCID 66671527 | 69% |
Reaction Steps
The compound (122 mg, 0.307 mol) obtained in Example 55b and the compound (171 mg, 0.368 mmol) obtained in Example 4g were used to give the title compound (181 mg; yield, 69%) as a colorless oily substance according to the method described in Example 45b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476253B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-0b1ef76f5778441bbc023b2a979d9b54 |
| Source note | uspto-grants-2013_07 |