HRID446556

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2756371

tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

C14H20N2O2

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCC=O

HCID86761901

未命名化合物

PRODUCTS

生成物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCNc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2

HCID86761910

未命名化合物

收率 19.1%

PROCEDURE

实验过程

tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (227 mg, 0.914 mmol) and the compound (638 mg, 1.37 mmol) obtained in Example 4g were used to give the title compound (122 mg; yield, 19%) as a colorless oily substance according to the method described in Example 45b.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c6d54f89a7574c55943588cd1e7c4452
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6][CH2:5]2.[C:19]1([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:26](=[O:46])[O:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][N:36]([CH3:45])[C:37](=[O:44])[CH2:38][CH2:39][CH2:40][CH2:41][CH:42]=O)[CH2:30][CH2:29]1>>[C:19]1([C:47]2[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=2)[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:26]([O:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][N:36]([CH3:45])[C:37](=[O:44])[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][NH:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6][CH2:5]3)[CH2:30][CH2:29]1)=[O:46]