6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline → HCID 86761910, compound

HRID 446556Notes

Reaction equation

HRID 446556 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6][CH2:5]2.[C:19]1([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:26](=[O:46])[O:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][N:36]([CH3:45])[C:37](=[O:44])[CH2:38][CH2:39][CH2:40][CH2:41][CH:42]=O)[CH2:30][CH2:29]1>>[C:19]1([C:47]2[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=2)[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:26]([O:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][N:36]([CH3:45])[C:37](=[O:44])[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][NH:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6][CH2:5]3)[CH2:30][CH2:29]1)=[O:46]

Participants

3

Reactant 2

HCID 27563716-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinolineHCID 867619011-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Product 1

HCID 86761910HCID 86761910, compoundYield 19.1%

Procedure

tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (227 mg, 0.914 mmol) and the compound (638 mg, 1.37 mmol) obtained in Example 4g were used to give the title compound (122 mg; yield, 19%) as a colorless oily substance according to the method described in Example 45b.

Sources & evidence

ORD record
ord-c6d54f89a7574c55943588cd1e7c4452
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

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