HCID 47028678, compound → HCID 86663460, compound

HRID 446566Notes

Reaction equation

HRID 446566 reaction equation
[CH3:1][N:2]([CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:24])[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=1)[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>CO.[C].[Pd]>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([C:14]([NH:13][CH2:12][CH2:11][CH2:10][N:2]([CH3:1])[C:3](=[O:9])[O:4][C:5]([CH3:7])([CH3:8])[CH3:6])=[O:24])=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 47028678HCID 47028678, compound

Product 1

HCID 86663460HCID 86663460, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

The compound (1.27 g, 3.78 mmol) obtained in Example 73b was dissolved in 40 mL of methanol, 100 mg of 10% palladium-carbon was added, and the mixture was stirred at room temperature under a hydrogen atmosphere for 2 hours. The reaction mixture was filtered through celite, and then the solvent of the filtrate was evaporated under reduced pressure to give the title compound (1.14 g; yield, 98%) as a colorless oily substance.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-86fab37194474b1d984f9a133224e382
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

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