Toluene → HCID 66671592, compound

HRID 446567Notes

Reaction equation

HRID 446567 reaction equation
[C:1]1([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:49])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:48])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]2[CH:32]=[CH:31][C:30]([C:33](=[O:47])[NH:34][CH2:35][CH2:36][CH2:37][N:38](C(OC(C)(C)C)=O)[CH3:39])=[CH:29][CH:28]=2)[CH3:19])[CH2:12][CH2:11]1.[ClH:56].CO.C1(C)C=CC=CC=1>ClCCl>[ClH:56].[ClH:56].[ClH:56].[C:1]1([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:49])[O:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][N:18]([CH3:19])[C:20](=[O:48])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]2[CH:28]=[CH:29][C:30]([C:33](=[O:47])[NH:34][CH2:35][CH2:36][CH2:37][NH:38][CH3:39])=[CH:31][CH:32]=2)[CH2:14][CH2:15]1

Participants

5

Reactant 3

HCID 1140TolueneHCID 21893726Hydrochloride methanolHCID 66671497HCID 66671497, compound

Product 1

HCID 66671592HCID 66671592, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (135 mg, 0.178 mmol) obtained in Example 73d was dissolved in 2.0 mL of dichloromethane, 2.0 mL of a 2 N hydrochloric acid-methanol solution was added, and the mixture was stirred at room temperature for 16 hours. 10 mL of toluene was added to the reaction mixture, and then the solvent was evaporated under reduced pressure to give a crude title compound.

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-7ad200def9084acba5bab66daa9052bf
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

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