反应详情

The compound (90 mg, 0.14 mmol) obtained in Example 74a was dissolved in a mixed solvent of methanol (1.4 mL) and water (1.4 mL), a 1 N aqueous sodium hydroxide solution (0.214 mL, 0.214 mmol) was added, and the mixture was stirred at room temperature for 3 hours and then at 50° C. for 2 hours. A 1 N aqueous hydrochloric acid solution (0.300 mL) and toluene were added, and then the solvent was evaporated under reduced pressure. The resulting residue and the compound (74 mg, 0.095 mmol) obtained in Example 1k were used to give the title compound (63 mg; yield, 48%) as a white solid according to the method described in Example 11e.

1. waitat 50° C. for 2 hours
2. customthe solvent was evaporated under reduced pressure