HRID446601

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21893726

Hydrochloride methanol

CH5ClO

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCNc1nc2ccc(C(=O)N(C)CCCN(C)C(=O)OC(C)(C)C)cc2s1

HCID86761918

未命名化合物

PRODUCTS

生成物

结构：CNCCCN(C)C(=O)c1ccc2nc(NCCCCCC(=O)N(C)CCN3CCC(OC(=O)Nc4ccccc4-c4ccccc4)CC3)sc2c1

HCID86761919

未命名化合物

收率 73%

PROCEDURE

实验过程

The compound (157 mg, 0.190 mmol) obtained in Example 93c and 2 N hydrochloric acid-methanol (1.90 mL, 3.79 mmol) were used to give the title compound (101 mg; yield, 73%) as a white solid according to the method described in Example 89e.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-140dc24cf6434129a6076a11b914cea6
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[C:1]1([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:53])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:52])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]2[S:28][C:29]3[CH:35]=[C:34]([C:36](=[O:51])[N:37]([CH2:39][CH2:40][CH2:41][N:42](C(OC(C)(C)C)=O)[CH3:43])[CH3:38])[CH:33]=[CH:32][C:30]=3[N:31]=2)[CH3:19])[CH2:12][CH2:11]1.Cl.CO>>[C:1]1([C:54]2[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:53])[O:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][N:18]([CH3:19])[C:20](=[O:52])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]2[S:28][C:29]3[CH:35]=[C:34]([C:36](=[O:51])[N:37]([CH3:38])[CH2:39][CH2:40][CH2:41][NH:42][CH3:43])[CH:33]=[CH:32][C:30]=3[N:31]=2)[CH2:14][CH2:15]1