HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → 1-[2-(Methyl{6-[(6-{methyl[3-(methylamino)propyl]carbamoyl}-1,3-benzothiazol-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | 1-(2-{[6-({6-[{3-([tert-Butoxycarbonyl)(methyl)amino]propyl}(methyl)carbamoyl]-1,3-benzothiazol-2-yl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate | HCID 86761918 | — |
| Product | 1-[2-(Methyl{6-[(6-{methyl[3-(methylamino)propyl]carbamoyl}-1,3-benzothiazol-2-yl)amino]hexanoyl}amino)ethyl]piperidin-4-yl biphenyl-2-ylcarbamate | HCID 86761919 | 73% |
Reaction Steps
The compound (157 mg, 0.190 mmol) obtained in Example 93c and 2 N hydrochloric acid-methanol (1.90 mL, 3.79 mmol) were used to give the title compound (101 mg; yield, 73%) as a white solid according to the method described in Example 89e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476253B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-140dc24cf6434129a6076a11b914cea6 |
| Source note | uspto-grants-2013_07 |