HRID446609

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(N)c(Cl)cc1C(=O)N(C)CCCN(C)C(=O)OC(C)(C)C

HCID86663478

未命名化合物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCC=O

HCID86761901

未命名化合物

PRODUCTS

生成物

结构：COc1cc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1C(=O)N(C)CCCN(C)C(=O)OC(C)(C)C

HCID66671766

未命名化合物

收率 43.9%

PROCEDURE

实验过程

The compound (219 mg, 0.57 mmol) obtained in Example 96a and the compound (294 mg, 0.63 mmol) obtained in Example 4g were used to give the title compound (209 mg; yield, 17%) as a white solid according to the method described in Example 18b.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-51585c2f045c4ffa9441407b026dd855
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([N:11]([CH3:24])[CH2:12][CH2:13][CH2:14][N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:10])=[C:4]([O:25][CH3:26])[CH:3]=1.[C:27]1([C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33][C:34](=[O:54])[O:35][CH:36]1[CH2:41][CH2:40][N:39]([CH2:42][CH2:43][N:44]([CH3:53])[C:45](=[O:52])[CH2:46][CH2:47][CH2:48][CH2:49][CH:50]=O)[CH2:38][CH2:37]1>>[C:27]1([C:55]2[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=2)[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33][C:34](=[O:54])[O:35][CH:36]1[CH2:41][CH2:40][N:39]([CH2:42][CH2:43][N:44]([C:45](=[O:52])[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][NH:1][C:2]2[CH:3]=[C:4]([O:25][CH3:26])[C:5]([C:9](=[O:10])[N:11]([CH2:12][CH2:13][CH2:14][N:15]([C:16]([O:17][C:18]([CH3:21])([CH3:19])[CH3:20])=[O:22])[CH3:23])[CH3:24])=[CH:6][C:7]=2[Cl:8])[CH3:53])[CH2:38][CH2:37]1