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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 446609Generated: October 26, 2026

tert-Butyl (3-{[(4-amino-5-chloro-2-methoxyphenyl)carbonyl](methyl)amino}propyl)methylcarbamate → 1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-chloro-5-methoxyphenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

https://huagongshe.com/reaction/446609

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl (3-{[(4-amino-5-chloro-2-methoxyphenyl)carbonyl](methyl)amino}propyl)methylcarbamateHCID 86663478—
Reactant1-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamateHCID 86761901—
Product1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(methyl)carbamoyl]-2-chloro-5-methoxyphenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamateHCID 6667176643.9%

Reaction Steps

The compound (219 mg, 0.57 mmol) obtained in Example 96a and the compound (294 mg, 0.63 mmol) obtained in Example 4g were used to give the title compound (209 mg; yield, 17%) as a white solid according to the method described in Example 18b.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08476253B2
Source datasetuspto-grants-2013_07
ORD IDord-51585c2f045c4ffa9441407b026dd855
Source noteuspto-grants-2013_07