HRID446621

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID13015612

未命名化合物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCN.Cl.Cl

HCID66671725

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)sc1C(=O)OC(C)(C)C

HCID86663486

未命名化合物

收率 29%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

tert-Butyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate (247 mg, 0.739 mmol), the compound (199 mg, 0.369 mmol) obtained in Example 11c, triethylamine (180 μL) and 4.0 mL of n-butanol were used to give the title compound (70 mg; yield, 29%) as a colorless oily substance according to the same procedure as in Example 104b.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bad5555039de41669897bffaaba4890e
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

Br[C:2]1[S:3][C:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1.Cl.Cl.[C:17]1([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:23][C:24](=[O:44])[O:25][CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][N:34]([C:36](=[O:43])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][NH2:42])[CH3:35])[CH2:28][CH2:27]1.C(N(CC)CC)C>C(O)CCC>[C:17]1([C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:23][C:24]([O:25][CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][N:34]([CH3:35])[C:36](=[O:43])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][NH:42][C:2]2[S:3][C:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=2)[CH2:28][CH2:27]1)=[O:44]