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HRID446653

反应详情

EQUATION

反应方程式

HRID 446653 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：C[Si](C)(C)C=[N+]=[N-]
HCID167693

未命名化合物

结构：CN(CCOCCOCCOCCOCCC(=O)O)C(=O)OC(C)(C)C
HCID86671296

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CCOCCOCCOCCOCCN(C)C(=O)OC(C)(C)C
HCID86671295

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CCCCCC
溶剂HCID8058

n-Hexane

C6H14

PROCEDURE

实验过程

2 ml of a 2M solution of trimethylsilyldiazomethane in hexane are added to a solution, cooled to 0° C., of 500 mg of 3-[2-(2-{2-[2-((tert-butoxycarbonyl)(methyl)amino)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid in 4.8 ml of MeOH. After 2 h, the mixture is neutralized by addition of 120 μl of acetic acid and then concentrated under RP, and the residue is purified by flash chromatography on silica (Analogix Super Flash SiO2 SF25-40 g) using a gradient from 0 to 5% of methanol in DCM. 400 mg of methyl 3-[2-(2-{2-[2-((tert-butoxycarbonyl)(methyl)amino)ethoxy]ethoxy}ethoxy)ethoxy]propanoate are thus obtained.

WORKUP

后处理

  1. concentrationconcentrated under RP
  2. customthe residue is purified by flash chromatography on silica (Analogix Super Flash SiO2 SF25-40 g)