Hydrochloric Acid → HCID 67027072, compound

Participants

Reaction Steps

Compound 1072 (69 g) was taken into 210 mL of methanol and 420 mL of 6M HCl and refluxed for 18 hrs. The reaction was cooled to room temperature and the pH adjusted to 8 with 6M sodium hydroxide. The resulting white precipitate was collected by vacuum filtration, washed well with water, and dried at 55° C. under vacuum overnight to afford 3-(1-(2,3-difluoro-4-methylphenyl)-1H-tetrazol-5-yl)pyridin-2-amine (62.32 g).

Provenance & Evidence