Hydrochloric Acid → HCID 67027072, compound

HRID 446733Notes

Reaction equation

HRID 446733 reaction equation
C([NH:5][C:6]1[C:11]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([F:24])[C:18]=3[F:25])[N:15]=[N:14][N:13]=2)=[CH:10][CH:9]=[CH:8][N:7]=1)(C)(C)C.Cl.[OH-].[Na+]>CO>[F:25][C:18]1[C:19]([F:24])=[C:20]([CH3:23])[CH:21]=[CH:22][C:17]=1[N:16]1[C:12]([C:11]2[C:6]([NH2:5])=[N:7][CH:8]=[CH:9][CH:10]=2)=[N:13][N:14]=[N:15]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67027122HCID 67027122, compound

Product 1

HCID 67027072HCID 67027072, compoundYield 107.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 1072 (69 g) was taken into 210 mL of methanol and 420 mL of 6M HCl and refluxed for 18 hrs. The reaction was cooled to room temperature and the pH adjusted to 8 with 6M sodium hydroxide. The resulting white precipitate was collected by vacuum filtration, washed well with water, and dried at 55° C. under vacuum overnight to afford 3-(1-(2,3-difluoro-4-methylphenyl)-1H-tetrazol-5-yl)pyridin-2-amine (62.32 g).

Workup

  1. temperaturerefluxed for 18 hrs
  2. filtrationThe resulting white precipitate was collected by vacuum filtration
  3. washwashed well with water
  4. customdried at 55° C. under vacuum overnight

Sources & evidence

ORD record
ord-85e641ed17284db58c962a93d2b7170a
Source dataset
uspto-grants-2013_07
Patent number
US08481524B2

Reaction notes

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