反应详情

A solution of 1-tritylpyrazolo[5,4-b]pyridine-4-carbothioamide (220 mg, 0.5232 mmol) and 3-bromo-1-methyl-2-oxo-cyclohexane-1-carbonitrile (125.0 mg, 0.5785 mmol) in EtOH (10 mL)/THF (1.5 mL) was heated at 90° C. overnight under nitrogen. The reaction mixture was concentrated in vacuo and purified by column chromatography (70:9:1 DCM/MeOH/NH4OH) to give a white solid after precipitation (67 mg, 39% Yield). MS (ES+) 296.08

1. concentrationThe reaction mixture was concentrated in vacuo
2. custompurified by column chromatography (70:9:1 DCM/MeOH/NH4OH)
3. customto give a white solid
4. customafter precipitation (67 mg, 39% Yield)