反应详情

To a stirred solution of compound ethyl 2-(4-hydroxyphenyl)acetate (30 g, 0.16 mol) in acetonitrile (300 mL) was added K2CO3 (114.9 g, 0.83 mol) and 2-(chloromethyl) quinoline (42.7 g, 0.19 mol) at RT. The reaction mixture was refluxed for 16 h, filtered and the resulting solid residue was extracted with EtOAc (2×100 mL). The combined organic layers were washed with water, dried over Na2SO4 and concentrated in vacuo to afford ethyl 2-(4-(quinolin-2-ylmethoxy)phenyl)acetate (50 g, 93%) as a solid.

1. temperatureThe reaction mixture was refluxed for 16 h
2. filtrationfiltered
3. extractionthe resulting solid residue was extracted with EtOAc (2×100 mL)
4. washThe combined organic layers were washed with water
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo