反应详情

To a solution of ethyl 2-(4-hydroxyphenyl)acetate (15 g, 0.09 mmol) in acetonitrile (100 mL) were added anhydrous K2CO3 (27.23 g, 0.19 mol) followed by Me2SO4 (14.94 g, 0.11 mol) at RT. The reaction mixture was then refluxed for 5 h, filtered through a pad of Celite® and the filtrate was concentrated in vacuo. The residue was dissolved in EtOAc (300 mL). The organic layer was then washed with water, dried over Na2SO4 and concentrated in vacuo to afford ethyl 2-(4-methoxyphenyl)acetate (16 g, 84%) as a solid.

1. temperatureThe reaction mixture was then refluxed for 5 h
2. filtrationfiltered through a pad of Celite®
3. concentrationthe filtrate was concentrated in vacuo
4. dissolutionThe residue was dissolved in EtOAc (300 mL)
5. washThe organic layer was then washed with water
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo