HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-chloro-4-methoxyphenyl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one → HCID 58368020, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-chloro-4-methoxyphenyl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one | HCID 58368006 | — |
| Reactant | 5-(2-Bromoacetyl)-2-methoxybenzonitrile | HCID 58368019 | — |
| Product | HCID 58368020 | HCID 58368020 | — |
Reaction Steps
Following the procedure for the preparation of 4-(3-chloro-4-methoxyphenyl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one-using 5-(2-bromoacetyl)-2-methoxybenzonitrile provided the title compound. 1H NMR (500 MHz, d6-DMSO): δ 8.32-8.28 (m, 1H), 8.06-7.95 (m, 2H), 7.81-7.76 (m, 2H), 7.62-7.56 (m, 1H), 7.49-7.39 (m, 2H), 7.26-7.18 (m, 3H), 7.12-7.05 (m, 2H), 5.41 (s, 2H), 5.33 (s, 2H), 3.89 (s, 3H). MS: M+H: m/z=449.0. HPLC: 91%, (Condition-H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481534B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b3dfc5d595a34e538356f9f5863b0490 |
| Source note | uspto-grants-2013_07 |