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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 446824Generated: October 27, 2026

4-(3-chloro-4-methoxyphenyl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one → HCID 58368020, compound

https://huagongshe.com/reaction/446824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(3-chloro-4-methoxyphenyl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-oneHCID 58368006—
Reactant5-(2-Bromoacetyl)-2-methoxybenzonitrileHCID 58368019—
ProductHCID 58368020HCID 58368020—

Reaction Steps

Following the procedure for the preparation of 4-(3-chloro-4-methoxyphenyl)-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one-using 5-(2-bromoacetyl)-2-methoxybenzonitrile provided the title compound. 1H NMR (500 MHz, d6-DMSO): δ 8.32-8.28 (m, 1H), 8.06-7.95 (m, 2H), 7.81-7.76 (m, 2H), 7.62-7.56 (m, 1H), 7.49-7.39 (m, 2H), 7.26-7.18 (m, 3H), 7.12-7.05 (m, 2H), 5.41 (s, 2H), 5.33 (s, 2H), 3.89 (s, 3H). MS: M+H: m/z=449.0. HPLC: 91%, (Condition-H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08481534B2
Source datasetuspto-grants-2013_07
ORD IDord-b3dfc5d595a34e538356f9f5863b0490
Source noteuspto-grants-2013_07