Hydrochloric Acid → HCID 67352780, compound

HRID 446849Notes

Reaction equation

HRID 446849 reaction equation
C(OC([N:6]1[CH2:30][C@:29]2([C:31](=[O:35])[CH2:32][S:33][CH3:34])[C@@H:8]([CH2:9][C@H:10]3[C@H:23]4[C@@:14]([F:27])([C@:15]5([CH3:26])[C:20]([C@@H:21]([F:24])[CH2:22]4)=[CH:19][C:18](=[O:25])[CH:17]=[CH:16]5)[C@@H:13]([OH:28])[CH2:12][C@@:11]32[CH3:36])[CH2:7]1)=O)=C.[ClH:37].O1CCOCC1>C(Cl)Cl>[ClH:37].[F:27][C@@:14]12[C@:15]3([CH3:26])[C:20](=[CH:19][C:18](=[O:25])[CH:17]=[CH:16]3)[C@@H:21]([F:24])[CH2:22][C@H:23]1[C@@H:10]1[CH2:9][C@@H:8]3[C@:29]([C:31](=[O:35])[CH2:32][S:33][CH3:34])([C@@:11]1([CH3:36])[CH2:12][C@@H:13]2[OH:28])[CH2:30][NH:6][CH2:7]3

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58392711HCID 58392711, compound

Product 1

HCID 67352780HCID 67352780, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of compound 185 (122 mg, 0.234 mmol) and HCl 4M in Dioxane (2 ml, 8.00 mmol) in DCM (10 ml) is stirred at RT for 2 hours, then the solvent is evaporated and the crude is dried in vacuo for 16 hours. MeOH (15 ml) is added and the solution is stirred at 45° C. for 20 minutes. The solvent is evaporated to afford the title compound (106 mg, 93% yield).

Workup

  1. customthe solvent is evaporated
  2. customthe crude is dried in vacuo for 16 hours
  3. additionMeOH (15 ml) is added
  4. stirringthe solution is stirred at 45° C. for 20 minutes
  5. customThe solvent is evaporated

Sources & evidence

ORD record
ord-e3e28b0cf4d149cb9335f7456a0cfdc1
Source dataset
uspto-grants-2013_07
Patent number
US08481517B2

Reaction notes

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