1-[2-(Pyrrolidin-1-yl)ethyl]piperazine → 4-[2-(2,4-Dichloro-benzoyl)-phenylsulfamoyl]-N-{2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-benzamide

HRID 446872Notes

Reaction equation

HRID 446872 reaction equation
[Cl:1][C:2]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][S:13]([C:16]1[CH:28]=[CH:27][C:19]([C:20]([NH:22][CH2:23][C:24]([OH:26])=O)=[O:21])=[CH:18][CH:17]=1)(=[O:15])=[O:14])=[O:5].[N:34]1([CH2:39][CH2:40][N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH2:38][CH2:37][CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][S:13]([C:16]1[CH:17]=[CH:18][C:19]([C:20]([NH:22][CH2:23][C:24](=[O:26])[N:44]2[CH2:43][CH2:42][N:41]([CH2:40][CH2:39][N:34]3[CH2:35][CH2:36][CH2:37][CH2:38]3)[CH2:46][CH2:45]2)=[O:21])=[CH:27][CH:28]=1)(=[O:14])=[O:15])=[O:5]

Participants

3

Reactant 2

HCID 27372501-[2-(Pyrrolidin-1-yl)ethyl]piperazineHCID 68492509{4-[2-(2,4-Dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid

Product 1

HCID 685774154-[2-(2,4-Dichloro-benzoyl)-phenylsulfamoyl]-N-{2-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-benzamide

Procedure

The title compound was prepared from {4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid and 1-(2-pyrrolidin-1-yl-ethyl)-piperazine (EMKA-Chemie) according to the method described in Example 1.1/f. MS (EI) 673.2 (MH+).

Sources & evidence

ORD record
ord-be4ce21d0f6d4917b47584af27b37824
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

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