4-(N-Boc-amino)piperidine → N-[2-(4-Amino-piperidin-1-yl)-2-oxo-ethyl]-4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzamide hydrochloride

HRID 446882Notes

Reaction equation

HRID 446882 reaction equation
[Cl:1][C:2]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][S:12]([C:15]1[CH:27]=[CH:26][C:18]([C:19]([NH:21][CH2:22][C:23](O)=[O:24])=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13].C(OC(=O)[NH:39][CH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)(C)(C)C>>[ClH:1].[NH2:39][CH:40]1[CH2:45][CH2:44][N:43]([C:23](=[O:24])[CH2:22][NH:21][C:19](=[O:20])[C:18]2[CH:26]=[CH:27][C:15]([S:12](=[O:13])(=[O:14])[NH:11][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][C:3]3[CH:28]=[CH:29][C:30]([Cl:32])=[CH:31][C:2]=3[Cl:1])=[CH:16][CH:17]=2)[CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 68493493{4-[2-(2,4-Dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetic acid

Product 1

HCID 68577155N-[2-(4-Amino-piperidin-1-yl)-2-oxo-ethyl]-4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzamide hydrochloride

Procedure

The title compound was prepared from {4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetic acid (Example 1.1/e) and piperidin-4-yl-carbamic acid tert-butyl ester (Aldrich) according to the method described in Example 11.1. MS (EI) 577.2 (MH±).

Sources & evidence

ORD record
ord-70f63c67f08e4c3789420ea9d591c14d
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

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