Tert-butyl 1,4-diazepane-1-carboxylate → N-(2-[1,4]Diazepan-1-yl-2-oxo-ethyl)-4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzamide hydrochloride

HRID 446883Notes

Reaction equation

HRID 446883 reaction equation
[Cl:1][C:2]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][S:13]([C:16]1[CH:28]=[CH:27][C:19]([C:20]([NH:22][CH2:23][C:24](O)=[O:25])=[O:21])=[CH:18][CH:17]=1)(=[O:15])=[O:14])=[O:5].C(OC([N:41]1[CH2:47][CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=O)(C)(C)C>>[ClH:1].[N:41]1([C:24](=[O:25])[CH2:23][NH:22][C:20](=[O:21])[C:19]2[CH:18]=[CH:17][C:16]([S:13](=[O:14])(=[O:15])[NH:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[C:4](=[O:5])[C:3]3[CH:29]=[CH:30][C:31]([Cl:33])=[CH:32][C:2]=3[Cl:1])=[CH:28][CH:27]=2)[CH2:47][CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylateHCID 68492509{4-[2-(2,4-Dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid

Product 1

HCID 68579610N-(2-[1,4]Diazepan-1-yl-2-oxo-ethyl)-4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzamide hydrochloride

Procedure

The title compound was prepared from {4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid (Example 6.1/c)) and [1,4]diazepane-1-carboxylic acid tert-butyl ester (Fluka) according to the method described in Example 11.1. MS (EI) 589.3 (MH+).

Sources & evidence

ORD record
ord-ddffdb00936b4db3939ac70bd4c1bb54
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

Loading…