tert-Butyl piperazine-1-carboxylate → 4-[2-(2,4-Dichloro-benzoyl)-phenylsulfamoyl]-N-(2-oxo-2-piperazin-1-yl-ethyl)-benzamide hydrochloride
Reaction equation
[Cl:1][C:2]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][S:13]([C:16]1[CH:28]=[CH:27][C:19]([C:20]([NH:22][CH2:23][C:24](O)=[O:25])=[O:21])=[CH:18][CH:17]=1)(=[O:15])=[O:14])=[O:5].C(OC([N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=O)(C)(C)C>>[ClH:1].[Cl:1][C:2]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][S:13]([C:16]1[CH:28]=[CH:27][C:19]([C:20]([NH:22][CH2:23][C:24](=[O:25])[N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)=[O:21])=[CH:18][CH:17]=1)(=[O:15])=[O:14])=[O:5]Participants
3
Procedure
The title compound was prepared from {4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid (Example 6.1/c)) and piperazine-1-carboxylic acid tert-butyl ester (Aldrich) according to the method described in Example 11.1. MS (EI) 575.3 (MH+).
Sources & evidence
- ORD record
- ord-00a10b6da80444c18b1451866eaf5322
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481527B2
Reaction notes
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