反应详情

To a solution of 1-(aminomethyl)cyclopentanol (approximately 55.2 mmol, prepared as described above) in dichloromethane (280 mL) was added triethylamine (7.76 mL, 55.7 mmol) and 4-chloro-3-nitroquinoline (9.22 g, 44.3 mmol). The mixture was allowed to stand at rt over the weekend. A solid formed that was isolated by filtration. Two more crops of solid were isolated from the mother liquor. The yellow solid was stirred in water and filtered. The solid was washed with water multiple times and was dried under vacuum with heat to give 1-{[(3-nitroquinolin-4-yl)amino]methyl}cyclopentanol as yellow crystals (8.29 g, 52%).

1. customto stand at rt over the weekend
2. customA solid formed that
3. customwas isolated by filtration
4. customTwo more crops of solid were isolated from the mother liquor
5. filtrationfiltered
6. washThe solid was washed with water multiple times
7. customwas dried under vacuum
8. temperaturewith heat