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HRID446949

反应详情

EQUATION

反应方程式

HRID 446949 的结构方程式

REACTANTS

反应物

1
结构：C[C@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12)C(=O)OC(C)(C)C
HCID67388507

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12)C(=O)O
HCID67387896

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：OCC(F)(F)F
溶剂HCID6409

2,2,2-Trifluoroethanol

C2H3F3O

PROCEDURE

实验过程

A solution of (S)-tert-butyl 2-(2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)propanoate (265 mg, 0.58 mmol) in 2,2,2-trifluoroethanol (4 mL) was heated at 150° C. for 3 h under microwave assisted conditions. The solvent was removed under vacuum to give 230 mg (98%) of (S)-2-(2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)propanoic acid as an oil.

WORKUP

后处理

  1. customThe solvent was removed under vacuum