HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → HCID 67216716, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester | HCID 67280928 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67216716 | HCID 67216716 | 101.7% |
Reaction Steps
A solution of 25 (1.4 g, 3.5 mmol) in MeOH (20 mL) was added to a solution of NaOMe (0.34 g, 6.3 mmol) in MeOH at ambient temperature. The reaction mixture was stirred for 16 h and then concentrated. The residue was diluted with EtOAc, washed successively with 1M HCl, brine, dried over anhydrous Na2SO4, filtered and concentrated to afford 13 as an orange-colored foam (1.39 g) that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481495B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-82c34970e411472690736a564dc8a0db |
| Source note | uspto-grants-2013_07 |